Phenotypic characterization of an Atp13a2 knockout rat model of Parkinson’s disease
Rémi Kinet, Joanna Sikora, Marie-Laure Arotcarena, Melina Decourt, Eric Balado, Evelyne Doudnikoff, Sylvain Bohic, Marta Vesnaver, Anna Lovisotto, Marie-Laure Thiolat, Nathalie Dutheil, Claire Mazzocco, Karim Harhouri, Rémy Steinschneider, Severine Menoret, Laurent Tesson, Ignacio Anegon, Michele Morari, Miquel Vila, François Georges, Erwan Bezard, Pierre-Olivier Fernagut, Benjamin Dehay
npj Parkinsons Dis.. 2025-11-18
10.1038/s41531-025-01171-0

Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology
Domenic Burger, Marianna Kashyrina, Lukas van den Heuvel, Hortense de La Seiglière, Amanda J. Lewis, Francesco De Nuccio, Inayathulla Mohammed, Jérémy Verchère, Cécile Feuillie, Mélanie Berbon, Marie-Laure Arotcarena, Aude Retailleau, Erwan Bezard, Marie-Hélène Canron, Wassilios G. Meissner, Antoine Loquet, Luc Bousset, Christel Poujol, K. Peter R. Nilsson, Florent Laferrière, Thierry Baron, Dario Domenico Lofrumento, Francesca De Giorgi, Henning Stahlberg, François Ichas
Nature. 2025-11-05
10.1038/s41586-025-09698-1

Differential Pathological Dynamics triggered by distinct Parkinson patient-derived α-synuclein extracts in non-human primates
R. Kinet, M. Bourdenx, S. Dovero, M. Darricau, M.-L. Arotcarena, S. Camus, G. Porras, M.-L. Thiolat, I. Trigo-Damas, S. Bohic, M. Morari, E. Doudnikoff, M. Goikoetxea, S. Claverol, C. Tokarski, N. Kruse, B. Mollenhauer, C. Estrada, N. Garcia-Carrillo, M. T. Herrero, M. Vila, J. A. Obeso, E. Bezard, B. Dehay
Sci. Adv.. 2025-06-20
10.1126/sciadv.adu6050

Additive effect of distant Lewy bodies and tau seeds injections on nigral degeneration in macaques
Morgane Darricau, Valentine Kulifaj, Marie-Laure Arotcarena, Qin Li, Taxiarchis Katsinelos, William A. McEwan, Maria Xilouri, Benjamin Dehay, Erwan Bezard, Vincent Planche
npj Parkinsons Dis.. 2025-04-13
10.1038/s41531-025-00938-9

Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space
J. Estaun-Panzano, S. Nandi, Q. Gresil, E. Doudnikoff, C. Mazzocco, ML. Arotcarena, MH. Canron, B. Dehay, L. Cognet, E. Bezard
npj Parkinsons Dis.. 2024-12-30
10.1038/s41531-024-00850-8

Nigral ATP13A2 depletion induces Parkinson’s disease-related neurodegeneration in a pilot study in non-human primates
Joanna Sikora, Sandra Dovero, Rémi Kinet, Marie-Laure Arotcarena, Sylvain Bohic, Erwan Bezard, Pierre-Olivier Fernagut, Benjamin Dehay
npj Parkinsons Dis.. 2024-08-01
10.1038/s41531-024-00757-4

Modeling Parkinson's Disease in Primates
Erwan Bezard, Margaux Teil, Marie-Laure Arotcarena, Gregory Porras, Qin Li, Benjamin Dehay
Cold Spring Harb Perspect Med. 2024-06-10
10.1101/cshperspect.a041612

Reconsidering α-Synuclein inclusion pathology in neurons, mice, and humans with an antibody sensing NAC engagement during α-Synuclein amyloid conversion
Francesca De Giorgi, Ænora Letourneur, Marianna Kashyrina, Federica Zinghirino, Sandra Dovero, Nathalie Dutheil, Leslie-Ann Largitte, Marie-Laure Arotçarena, Erwan Bezard, Marie-Hélène Canron, Wassilios Meissner, Francesco De Nuccio, Dario Domenico Lofrumento, Florent Laferrière, François Ichas
Preprint - Research Square. 2024-02-07
10.21203/rs.3.rs-3921168/v1

Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain
Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Morgane Darricau, Gregory Porras, Marie-Laure Thiolat, Inés Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, María Trinidad Herrero, Miquel Vila, José A. Obeso, Erwan Bezard, Benjamin Dehay
npj Parkinsons Dis.. 2023-09-19
10.1038/s41531-023-00579-w

Monitoring α-synuclein aggregation.
Juan Estaun-Panzano, Marie-Laure Arotcarena, Erwan Bezard
Neurobiology of Disease. 2023-01-01
10.1016/j.nbd.2022.105966

Acidic nanoparticles protect against α-synuclein-induced neurodegeneration through the restoration of lysosomal function.
Arotcarena ML, Soria FN, Cunha A, Doudnikoff E, Prévot G, Daniel J, Blanchard-Desce M, Barthélémy P, Bezard E, Crauste-Manciet S, Dehay B.
Aging cell.
10.1111/acel.13584

Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology
Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Sandrine Camus, Gregory Porras, Marie-Laure Thiolat, Ines Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, Michele Morari, Wassilios G Meissner, María Trinidad Herrero, Miquel Vila, Jose A Obeso, Erwan Bezard, Benjamin Dehay
Brain. 2022-03-14
10.1093/brain/awab374

Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques
Marie-Laure Arotcarena, Sandra Dovero, Nathalie Biendon, Nathalie Dutheil, Vincent Planche, Erwan Bezard, Benjamin Dehay
Front. Bioeng. Biotechnol.. 2021-11-15
10.3389/fbioe.2021.762209

Lack of limbic-predominant age-related TDP-43 encephalopathy (LATE) neuropathological changes in aged macaques with memory impairment
Morgane Darricau, Marie-Hélène Canron, Marion Bosc, Marie-Laure Arotçarena, Mégane Le Quang, Benjamin Dehay, Erwan Bezard, Vincent Planche
Neurobiology of Aging. 2021-11-01
10.1016/j.neurobiolaging.2021.07.009

A New Rise of Non-Human Primate Models of Synucleinopathies
Margaux Teil, Marie-Laure Arotcarena, Benjamin Dehay
Biomedicines. 2021-03-09
10.3390/biomedicines9030272

Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling
Federico N. Soria, Chiara Paviolo, Evelyne Doudnikoff, Marie-Laure Arotcarena, Antony Lee, Noémie Danné, Amit Kumar Mandal, Philippe Gosset, Benjamin Dehay, Laurent Groc, Laurent Cognet, Erwan Bezard
Nat Commun. 2020-07-10
10.1038/s41467-020-17328-9

Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates
M. Bourdenx, A. Nioche, S. Dovero, M.-L. Arotcarena, S. Camus, G. Porras, M.-L. Thiolat, N. P. Rougier, A. Prigent, P. Aubert, S. Bohic, C. Sandt, F. Laferrière, E. Doudnikoff, N. Kruse, B. Mollenhauer, S. Novello, M. Morari, T. Leste-Lasserre, I. Trigo Damas, M. Goillandeau, C. Perier, C. Estrada, N. Garcia-Carrillo, A. Recasens, N. N. Vaikath, O. M. A. El-Agnaf, M. T. Herrero, P. Derkinderen, M. Vila, J. A. Obeso, B. Dehay, E. Bezard
Sci. Adv.. 2020-05-01
10.1126/sciadv.aaz9165

Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates
Marie-Laure Arotcarena, Sandra Dovero, Alice Prigent, Mathieu Bourdenx, Sandrine Camus, Gregory Porras, Marie-Laure Thiolat, Maddalena Tasselli, Philippe Aubert, Niels Kruse, Brit Mollenhauer, Ines Trigo Damas, Cristina Estrada, Nuria Garcia-Carrillo, Nishant N Vaikath, Omar M A El-Agnaf, Maria Trinidad Herrero, Miquel Vila, Jose A Obeso, Pascal Derkinderen, Benjamin Dehay, Erwan Bezard
Brain. 2020-05-01
10.1093/brain/awaa096

Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts
Margaux Teil, Marie-Laure Arotcarena, Emilie Faggiani, Florent Laferriere, Erwan Bezard, Benjamin Dehay
Biomolecules. 2020-03-03
10.3390/biom10030391

Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in non-human primates
M. Bourdenx, A. Nioche, S. Dovero, M.-L. Arotcarena, S. Camus, G. Porras, M.-L. Thiolat, N. P. Rougier, A. Prigent, P. Aubert, S. Bohic, C. Sandt, F. Laferrière, E. Doudnikoff, N. Kruse, B. Mollenhauer, S. Novello, M. Morari, T. Leste-Lasserre, I. Trigo Damas, M. Goillandeau, C. Perier, C. Estrada, N. Garcia-Carrillo, A. Recasens, N. N. Vaikath, O. M. A. El-Agnaf, M. Trinidad Herrero, P. Derkinderen, M. Vila, J. A. Obeso, B. Dehay, E. Bezard
. 2019-10-31
10.1101/825216

Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
Marie-Laure Arotcarena, Mathieu Bourdenx, Nathalie Dutheil, Marie-Laure Thiolat, Evelyne Doudnikoff, Sandra Dovero, Andrea Ballabio, Pierre-Olivier Fernagut, Wassilios G. Meissner, Erwan Bezard, Benjamin Dehay
JCI Insight. 2019-08-22
10.1172/jci.insight.129719

Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery
Marie-Laure Arotcarena, Margaux Teil, Benjamin Dehay
Cells. 2019-06-09
10.3390/cells8060565

Are synucleinopathies prion-like disorders?,Les synucléinopathies sont-elles des maladies à prions ?
M.-L. Arotçarena, B. Dehay
Pratique Neurologique - FMC. 2018-04-01
10.1016/j.praneu.2018.02.006